/* =============================================
   PULPNEURO — MAIN STYLESHEET
   Brand colors from pitch deck:
   --navy:     #0A1527  (deep dark background)
   --navy-mid: #162951  (slightly lighter panel)
   --blue:     #1B3BCC  (section header blue)
   --blue-bright: #0618E9 (logo/accent blue)
   --white:    #FFFFFF
   --black:    #0A0A0A  (logo text)
   ============================================= */

:root {
  --navy:        #0A1527;
  --navy-mid:    #162951;
  --blue:        #1B3BCC;
  --blue-bright: #0618E9;
  --blue-light:  #E8EDFF;
  --blue-mid:    #2B45D4;
  --white:       #FFFFFF;
  --off-white:   #F4F6FB;
  --gray-100:    #E8ECF4;
  --gray-300:    #B8C0D4;
  --gray-500:    #6B7590;
  --gray-700:    #353D58;
  --black:       #0A0A0A;
  --text:        #1A2038;
  --font-display: 'DM Serif Display', Georgia, serif;
  --font-body:    'Inter', system-ui, sans-serif;
  --nav-h:       72px;
  --radius:      8px;
  --radius-lg:   14px;
  --shadow:      0 2px 16px rgba(10,21,39,0.12);
  --shadow-lg:   0 8px 40px rgba(10,21,39,0.20);
}

*, *::before, *::after { box-sizing: border-box; margin: 0; padding: 0; }
html { scroll-behavior: smooth; }
body {
  font-family: var(--font-body);
  font-size: 16px;
  line-height: 1.65;
  color: var(--text);
  background: var(--white);
  -webkit-font-smoothing: antialiased;
}
img { max-width: 100%; display: block; }
a { color: inherit; text-decoration: none; }

/* ---- TYPOGRAPHY ---- */
h1, h2, h3, h4 { font-family: var(--font-display); line-height: 1.15; }
h1 { font-size: clamp(2.4rem, 5vw, 4rem); }
h2 { font-size: clamp(1.8rem, 3.2vw, 2.6rem); margin-bottom: 1rem; }
h3 { font-size: 1.2rem; margin-bottom: 0.5rem; }
h4 { font-size: 1rem; margin-bottom: 0.35rem; }
p  { margin-bottom: 1rem; color: var(--gray-700); }
p:last-child { margin-bottom: 0; }
em { font-style: italic; }

.eyebrow {
  font-size: 0.75rem;
  font-weight: 700;
  letter-spacing: 0.14em;
  text-transform: uppercase;
  color: var(--blue);
  margin-bottom: 0.75rem;
}
.centered { text-align: center; }
.section-intro { font-size: 1.05rem; max-width: 680px; margin-bottom: 2.5rem; color: var(--gray-700); }

/* ---- CONTAINER ---- */
.container { max-width: 1140px; margin: 0 auto; padding: 0 24px; }
.container-narrow { max-width: 760px; margin: 0 auto; padding: 0 24px; }
.container-2col {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 64px;
  align-items: center;
}
@media (max-width: 768px) {
  .container-2col { grid-template-columns: 1fr; gap: 36px; }
}

/* ---- NAV ---- */
.nav {
  position: fixed; top: 0; left: 0; right: 0; z-index: 100;
  height: var(--nav-h);
  background: var(--navy);
  border-bottom: 1px solid rgba(255,255,255,0.06);
  transition: box-shadow 0.3s;
}
.nav.scrolled { box-shadow: 0 2px 24px rgba(0,0,0,0.4); }
.nav-inner {
  max-width: 1140px; margin: 0 auto; padding: 0 24px;
  height: 100%; display: flex; align-items: center; justify-content: space-between;
}
.nav-logo {
  display: flex; align-items: center;
  height: 44px;
}
.nav-logo img {
  height: 44px;
  width: auto;
}
.nav-links {
  display: flex; align-items: center; gap: 32px; list-style: none;
}
.nav-links a {
  color: rgba(255,255,255,0.78); font-size: 0.9rem; font-weight: 500;
  transition: color 0.2s;
}
.nav-links a:hover { color: var(--white); }
.nav-cta {
  background: var(--blue) !important;
  color: var(--white) !important;
  padding: 9px 22px; border-radius: 6px; font-weight: 600 !important;
  transition: background 0.2s !important;
}
.nav-cta:hover { background: var(--blue-mid) !important; }
.nav-hamburger {
  display: none; flex-direction: column; gap: 5px;
  background: none; border: none; cursor: pointer; padding: 4px;
}
.nav-hamburger span { display: block; width: 24px; height: 2px; background: var(--white); border-radius: 2px; }
@media (max-width: 768px) {
  .nav-links { display: none; }
  .nav-hamburger { display: flex; }
  .nav-links.open {
    display: flex; flex-direction: column; align-items: flex-start;
    position: absolute; top: var(--nav-h); left: 0; right: 0;
    background: var(--navy); padding: 24px; gap: 20px;
    border-top: 1px solid rgba(255,255,255,0.1);
  }
}

/* ---- HERO ---- */
.hero {
  position: relative; min-height: 100vh;
  display: flex; align-items: center;
  padding: calc(var(--nav-h) + 48px) 24px 80px;
  overflow: hidden;
}
.hero-bg {
  position: absolute; inset: 0;
  background-size: cover; background-position: center;
}
.hero-overlay {
  position: absolute; inset: 0;
  background: linear-gradient(110deg, rgba(10,21,39,0.92) 45%, rgba(10,21,39,0.55) 100%);
}
.hero-content {
  position: relative; z-index: 2;
  max-width: 640px;
  margin-left: calc((100vw - 1140px) / 2);
}
@media (max-width: 1188px) { .hero-content { margin-left: 0; } }

.hero-logo {
  height: 70px; width: auto; margin-bottom: 2rem;
}
.hero-tagline {
  font-size: 0.78rem; font-weight: 700; letter-spacing: 0.14em;
  text-transform: uppercase; color: rgba(255,255,255,0.5); margin-bottom: 1.25rem;
}
.hero-title {
  font-family: var(--font-display);
  font-size: clamp(2.8rem, 5.5vw, 4.8rem);
  line-height: 1.08; color: var(--white); margin-bottom: 1.5rem;
}
.hero-title em { color: #6B8AFF; font-style: italic; }
.hero-sub {
  font-size: 1.1rem; line-height: 1.7;
  color: rgba(255,255,255,0.75); margin-bottom: 2.5rem; max-width: 520px;
}
.hero-actions { display: flex; gap: 14px; flex-wrap: wrap; }
.hero-scroll {
  position: absolute; bottom: 32px; left: 50%;
  transform: translateX(-50%); color: rgba(255,255,255,0.3);
  font-size: 1.3rem; animation: bounce 2.5s infinite;
}
@keyframes bounce {
  0%, 100% { transform: translateX(-50%) translateY(0); }
  50% { transform: translateX(-50%) translateY(8px); }
}

/* ---- BUTTONS ---- */
.btn {
  display: inline-block; padding: 13px 28px; border-radius: 6px;
  font-size: 0.92rem; font-weight: 600; letter-spacing: 0.01em;
  transition: all 0.2s; cursor: pointer; border: none;
}
.btn-primary { background: var(--blue); color: var(--white); }
.btn-primary:hover { background: var(--blue-mid); transform: translateY(-1px); box-shadow: 0 4px 20px rgba(27,59,204,0.4); }
.btn-ghost {
  background: transparent; color: var(--white);
  border: 1.5px solid rgba(255,255,255,0.4);
}
.btn-ghost:hover { border-color: var(--white); background: rgba(255,255,255,0.08); }
.btn-ghost-light {
  background: transparent; color: var(--white);
  border: 1.5px solid rgba(255,255,255,0.45);
  padding: 13px 28px; border-radius: 6px; font-weight: 600;
  display: inline-block; transition: all 0.2s;
}
.btn-ghost-light:hover { background: rgba(255,255,255,0.1); border-color: var(--white); }
.link-arrow {
  font-weight: 600; font-size: 0.9rem; color: var(--blue);
  display: inline-flex; align-items: center; gap: 4px; transition: gap 0.2s;
}
.link-arrow:hover { gap: 8px; }

/* ---- STATS BAR ---- */
.stats-bar { background: var(--navy); padding: 36px 0; border-bottom: 1px solid rgba(255,255,255,0.06); }
.stats-bar .container {
  display: flex; align-items: center; justify-content: center;
  gap: 0; flex-wrap: wrap;
}
.stat { text-align: center; padding: 8px 44px; }
.stat-n {
  display: block; font-family: var(--font-display);
  font-size: 2.6rem; color: var(--white); line-height: 1;
}
.stat-label { font-size: 0.75rem; color: rgba(255,255,255,0.45); letter-spacing: 0.06em; text-transform: uppercase; margin-top: 4px; }
.stat-div { width: 1px; height: 52px; background: rgba(255,255,255,0.1); }
@media (max-width: 600px) {
  .stat { padding: 12px 20px; }
  .stat-div { display: none; }
}

/* ---- SECTIONS ---- */
.section { padding: 96px 0; }
.section-white { background: var(--white); }
.section-light { background: var(--off-white); }
.section-navy { background: var(--navy); color: var(--white); }
.section-navy h2, .section-navy h3, .section-navy .eyebrow { color: var(--white); }
.section-navy .eyebrow { color: rgba(255,255,255,0.5); }
.section-navy p { color: rgba(255,255,255,0.65); }
.section-blue {
  background: var(--blue); color: var(--white); padding: 96px 0;
}
.section-blue h2, .section-blue p { color: var(--white); }
.section-blue .eyebrow { color: rgba(255,255,255,0.6); }
.section-blue p { color: rgba(255,255,255,0.85); font-size: 1.05rem; margin-bottom: 1.25rem; }

/* ---- CARDS ---- */
.card-grid-3 {
  display: grid; grid-template-columns: repeat(3, 1fr); gap: 24px; margin-top: 3rem;
}
@media (max-width: 768px) { .card-grid-3 { grid-template-columns: 1fr; } }

.platform-card {
  background: rgba(255,255,255,0.04);
  border: 1px solid rgba(255,255,255,0.09);
  border-radius: var(--radius-lg); padding: 32px;
  transition: background 0.2s, transform 0.2s;
}
.platform-card:hover { background: rgba(255,255,255,0.08); transform: translateY(-2px); }
.card-icon { font-size: 1.5rem; margin-bottom: 1rem; }
.platform-card h3 { color: var(--white); }

/* ---- DISEASE GRID ---- */
.disease-grid {
  display: grid; grid-template-columns: repeat(4, 1fr); gap: 18px; margin-top: 2.5rem;
}
@media (max-width: 900px) { .disease-grid { grid-template-columns: repeat(2, 1fr); } }
@media (max-width: 500px) { .disease-grid { grid-template-columns: 1fr; } }

.disease-card {
  display: block; background: var(--white);
  border: 1px solid var(--gray-100); border-radius: var(--radius-lg); padding: 26px 22px;
  transition: box-shadow 0.2s, transform 0.2s;
}
.disease-card:hover { box-shadow: var(--shadow-lg); transform: translateY(-2px); }
.disease-tag {
  display: inline-block; background: var(--blue-light); color: var(--blue);
  font-size: 0.7rem; font-weight: 700; letter-spacing: 0.08em;
  padding: 4px 10px; border-radius: 4px; margin-bottom: 10px;
}
.disease-card h4 { font-size: 0.98rem; margin-bottom: 0.4rem; }
.disease-card p { font-size: 0.86rem; color: var(--gray-500); margin: 0; }

/* ---- PUBLICATIONS TEASER ---- */
.pub-teaser-list { display: flex; flex-direction: column; margin-top: 2rem; }
.pub-teaser {
  display: grid; grid-template-columns: 60px 1fr auto;
  align-items: center; gap: 24px;
  padding: 20px 0; border-bottom: 1px solid var(--gray-100);
}
.pub-teaser:first-child { border-top: 1px solid var(--gray-100); }
.pub-year { font-family: var(--font-display); font-size: 1.3rem; color: var(--blue); }
.pub-title { font-weight: 500; font-size: 0.93rem; margin-bottom: 2px; color: var(--text); }
.pub-journal { font-size: 0.82rem; color: var(--gray-500); }
.pub-link { font-size: 0.82rem; font-weight: 600; color: var(--blue); white-space: nowrap; transition: color 0.2s; }
.pub-link:hover { color: var(--blue-bright); }

/* ---- IMAGES ---- */
.rounded-img { border-radius: var(--radius-lg); box-shadow: var(--shadow-lg); width: 100%; }
.img-caption { font-size: 0.76rem; color: var(--gray-500); margin-top: 10px; line-height: 1.4; }

/* ---- PAGE HERO (inner pages) ---- */
.page-hero {
  background: var(--navy);
  padding: calc(var(--nav-h) + 56px) 0 56px;
  color: var(--white);
  border-bottom: 3px solid var(--blue);
}
.page-hero .eyebrow { color: rgba(255,255,255,0.45); }
.page-hero h1 { font-size: clamp(2rem, 4vw, 3rem); color: var(--white); margin-bottom: 1rem; }
.page-hero p { color: rgba(255,255,255,0.7); font-size: 1.05rem; max-width: 580px; }

/* ---- FOOTER ---- */
.footer { background: var(--navy); color: rgba(255,255,255,0.6); padding: 64px 0 0; border-top: 1px solid rgba(255,255,255,0.06); }
.footer-inner {
  display: grid; grid-template-columns: 1.2fr 1fr; gap: 64px;
  padding-bottom: 48px; border-bottom: 1px solid rgba(255,255,255,0.07);
}
@media (max-width: 640px) { .footer-inner { grid-template-columns: 1fr; gap: 40px; } }
.footer-logo { height: 50px; width: auto; margin-bottom: 16px; }
.footer-brand p { font-size: 0.88rem; line-height: 1.6; color: rgba(255,255,255,0.45); }
.footer-location { font-size: 0.76rem; color: rgba(255,255,255,0.3); margin-top: 6px; }
.footer-links { display: flex; gap: 48px; }
.footer-col { display: flex; flex-direction: column; gap: 10px; }
.footer-col-head { font-size: 0.74rem; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: rgba(255,255,255,0.35); margin-bottom: 4px; }
.footer-col a { font-size: 0.86rem; color: rgba(255,255,255,0.55); transition: color 0.2s; }
.footer-col a:hover { color: var(--white); }
.footer-bottom { padding: 20px 0; font-size: 0.76rem; color: rgba(255,255,255,0.25); }

/* ---- PIPELINE ---- */
.pipeline-steps {
  display: grid; grid-template-columns: repeat(6, 1fr);
  margin: 3rem 0; position: relative;
}
.pipeline-steps::before {
  content: ''; position: absolute; top: 28px; left: 8%;
  width: 84%; height: 2px; background: var(--blue); z-index: 0; opacity: 0.4;
}
.pipeline-step { text-align: center; position: relative; z-index: 1; padding: 0 6px; }
.step-circle {
  width: 56px; height: 56px; border-radius: 50%;
  background: var(--navy); border: 2px solid var(--blue);
  display: flex; align-items: center; justify-content: center;
  margin: 0 auto 12px; font-weight: 700; color: var(--white);
  font-size: 0.85rem;
}
.step-label { font-size: 0.73rem; font-weight: 600; color: rgba(255,255,255,0.7); line-height: 1.4; }
.step-sub { font-size: 0.68rem; color: rgba(255,255,255,0.35); }
@media (max-width: 700px) {
  .pipeline-steps { grid-template-columns: repeat(3, 1fr); gap: 20px; }
  .pipeline-steps::before { display: none; }
}

/* ---- PUBLICATIONS PAGE ---- */
.pub-list { margin-top: 2.5rem; }
.pub-item {
  display: grid; grid-template-columns: 56px 1fr;
  gap: 20px; padding: 24px 0; border-bottom: 1px solid var(--gray-100);
}
.pub-item:first-child { border-top: 1px solid var(--gray-100); }
.pub-num { font-family: var(--font-display); font-size: 1.4rem; color: var(--gray-300); padding-top: 2px; }
.pub-body .pub-title { font-weight: 600; font-size: 0.96rem; margin-bottom: 4px; color: var(--text); }
.pub-body .pub-authors { font-size: 0.83rem; color: var(--gray-500); margin-bottom: 5px; }
.pub-body .pub-meta { font-size: 0.81rem; color: var(--gray-500); display: flex; gap: 12px; flex-wrap: wrap; align-items: center; }
.pub-badge {
  display: inline-block; background: var(--blue-light); color: var(--blue);
  font-size: 0.69rem; font-weight: 700; letter-spacing: 0.05em;
  padding: 2px 8px; border-radius: 4px;
}
.pub-pmid a { color: var(--blue); font-weight: 600; transition: color 0.2s; }
.pub-pmid a:hover { color: var(--blue-bright); }

/* ---- DISEASE PAGE ---- */
.disease-section { padding: 64px 0; border-bottom: 1px solid var(--gray-100); }
.disease-section:last-child { border-bottom: none; }
.disease-header { display: flex; align-items: center; gap: 14px; margin-bottom: 1.5rem; }
.disease-badge {
  background: var(--blue); color: var(--white);
  font-size: 0.78rem; font-weight: 700; padding: 6px 14px;
  border-radius: 5px; white-space: nowrap;
}
.disease-cell-count { font-size: 0.82rem; color: var(--gray-500); }
.disease-body { display: grid; grid-template-columns: 1fr 270px; gap: 48px; }
@media (max-width: 768px) { .disease-body { grid-template-columns: 1fr; } }
.disease-stats-box {
  background: var(--blue-light); border-radius: var(--radius-lg); padding: 22px; align-self: start;
}
.ds-row { display: flex; justify-content: space-between; padding: 8px 0; border-bottom: 1px solid rgba(27,59,204,0.1); font-size: 0.86rem; }
.ds-row:last-child { border: none; }
.ds-label { color: var(--gray-700); }
.ds-val { font-weight: 600; color: var(--blue); }

/* ---- CONTACT ---- */
.contact-wrap { display: grid; grid-template-columns: 1fr 1fr; gap: 64px; margin-top: 3rem; }
@media (max-width: 700px) { .contact-wrap { grid-template-columns: 1fr; } }
.contact-form input, .contact-form textarea {
  width: 100%; padding: 11px 14px;
  border: 1px solid var(--gray-300); border-radius: var(--radius);
  font-family: var(--font-body); font-size: 0.93rem; margin-bottom: 14px;
  transition: border-color 0.2s; outline: none;
  background: var(--white); color: var(--text);
}
.contact-form input:focus, .contact-form textarea:focus { border-color: var(--blue); }
.contact-form textarea { min-height: 130px; resize: vertical; }
.contact-form label { font-size: 0.8rem; font-weight: 600; color: var(--gray-700); display: block; margin-bottom: 5px; }
.contact-info-item { display: flex; gap: 12px; margin-bottom: 22px; }
.ci-icon { font-size: 1.1rem; }
.ci-text { font-size: 0.88rem; color: var(--gray-700); line-height: 1.5; }
.ci-text strong { display: block; color: var(--text); font-weight: 600; margin-bottom: 2px; }

/* ---- TEAM ---- */
.team-photo {
  border-radius: var(--radius-lg); box-shadow: var(--shadow-lg);
  object-fit: cover;
}